Synaptic neurexin complexes: a molecular code for the logic of neural circuits

TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

GABAergic system dysfunction in autism spectrum disorders

H Zhao, X Mao, C Zhu, X Zou, F Peng… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases
characterized by two hallmark symptoms, social communication deficits and repetitive …

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky… - Elife, 2021 - elifesciences.org
The study of naturalistic social behavior requires quantification of animals' interactions. This
is generally done through manual annotation—a highly time-consuming and tedious …

Neurophysiology and regulation of the balance between excitation and inhibition in neocortical circuits

R Tatti, MS Haley, OK Swanson, T Tselha, A Maffei - Biological psychiatry, 2017 - Elsevier
Brain function relies on the ability of neural networks to maintain stable levels of activity,
while experiences sculpt them. In the neocortex, the balance between activity and stability …

Neuroligin-3: a circuit-specific synapse organizer that shapes normal function and autism spectrum disorder-associated dysfunction

M Uchigashima, A Cheung, K Futai - Frontiers in Molecular …, 2021 - frontiersin.org
Chemical synapses provide a vital foundation for neuron-neuron communication and overall
brain function. By tethering closely apposed molecular machinery for presynaptic …

Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder

S Nisar, M Haris - Molecular psychiatry, 2023 - nature.com
Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early
childhood and are characterized by qualitative abnormalities in social behaviors …

Neural mechanisms underlying repetitive behaviors in rodent models of autism spectrum disorders

T Gandhi, CC Lee - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

Roles of neuroligins in central nervous system development: focus on glial neuroligins and neuron neuroligins

X Liu, F Hua, D Yang, Y Lin, L Zhang, J Ying… - Journal of translational …, 2022 - Springer
Neuroligins are postsynaptic cell adhesion molecules that are relevant to many
neurodevelopmental disorders. They are differentially enriched at the postsynapse and …

The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses

MN Hill, M Haney, CJ Hillard, DS Karhson… - Psychological …, 2023 - cambridge.org
Cannabis is well established to impact affective states, emotion and perceptual processing,
primarily through its interactions with the endocannabinoid system. While cannabis use is …

Gastrointestinal dysfunction in patients and mice expressing the autism‐associated R451C mutation in neuroligin‐3

S Hosie, M Ellis, M Swaminathan… - Autism …, 2019 - Wiley Online Library
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with
autism. Multiple mutations in the neuroligin family of synaptic adhesion molecules are …