Human islet amyloid polypeptide: A therapeutic target for the management of type 2 diabetes mellitus

PH Roham, SN Save, S Sharma - Journal of Pharmaceutical Analysis, 2022 - Elsevier
Type 2 diabetes mellitus (T2DM) and other metabolic disorders are often silent and go
unnoticed in patients because of the lack of suitable prognostic and diagnostic markers. The …

Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin

S Nurdiana, YM Goh, H Ahmad, SM Dom… - … and alternative medicine, 2017 - Springer
Background The potential application of Ficus deltoidea and vitexin for the management of
symptomatologies associated with diabetes mellitus (DM) has gained much attention …

Fluorine functionalized graphene quantum dots as inhibitor against hIAPP amyloid aggregation

M Yousaf, H Huang, P Li, C Wang… - ACS chemical …, 2017 - ACS Publications
Fibrillar deposits of the human islet amyloid polypeptide (hIAPP) are considered as a root of
Type II diabetes mellitus. Fluorinated graphene quantum dots (FGQDs) are new carbon …

[HTML][HTML] MnSOD Mimetics in Therapy: Exploring Their Role in Combating Oxidative Stress-Related Diseases

J Grujicic, AR Allen - Antioxidants, 2024 - mdpi.com
Reactive oxygen species (ROS) are double-edged swords in biological systems—they are
essential for normal cellular functions but can cause damage when accumulated due to …

Effect of Caesalpinia bonduc polyphenol extract on Alloxan‐induced diabetic rats in attenuating hyperglycemia by upregulating insulin secretion and inhibiting JNK …

A Iftikhar, B Aslam, M Iftikhar, W Majeed… - Oxidative Medicine …, 2020 - Wiley Online Library
Caesalpinia bonduc has been used in herbal medicines for the treatment of a wide range of
diseases from decades. The present study has explored the remedial potential and …

Introduction and fundamentals of human islet amyloid polypeptide inhibitors

Y Tang, D Zhang, Y Zhang, Y Liu, X Gong… - ACS Applied Bio …, 2020 - ACS Publications
Type 2 diabetes (T2D) is a common protein misfolding disease (PMD), and its pathogenesis
is considered to be tightly associated with the aggregation of the disease-causative hIAPP …

Inhibition of human amylin aggregation and cellular toxicity by lipoic acid and ascorbic acid

SK Azzam, H Jang, MC Choi, H Alsafar… - Molecular …, 2018 - ACS Publications
More than 30 human degenerative diseases result from protein aggregation such as
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). Islet amyloid deposits, a …

Repurposing a cardiovascular disease drug of cloridarol as hIAPP inhibitor

Y Tang, Y Liu, Y Zhang, D Zhang… - ACS Chemical …, 2021 - ACS Publications
Accumulating evidence have shown a strong pathological correlation between
cardiovascular disease (CVD) and Type II diabetes (T2D), both of which share many …

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

CE Strong, J Zhang, M Carrasco, S Kundu… - Communications …, 2023 - nature.com
Abstract 3D spheroids have emerged as powerful drug discovery tools given their high-
throughput screening (HTS) compatibility. Here, we describe a method for generating …

Anti-obesity and anti-diabetic effect of ursolic acid against streptozotocin/high fat induced obese in diabetic rats

S Tang, C Fang, Y Liu, L Tang, Y Xu - Journal of Oleo Science, 2022 - jstage.jst.go.jp
Obesity is occurring due to continue taken high fat diet; this is the fast-growing problem
reaching epidemic proportion globally. Ursolic acid altered the abnormal glucose …