Investigators have made key advances in rheumatoid arthritis (RA) genetics in the past 10
years. Although genetic studies have had limited influence on clinical practice and drug …

Autoimmune disease: why and where it occurs | Nature Medicine Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

There is increasing evidence that genome-wide association (GWA) studies represent a
powerful approach to the identification of genes involved in common human diseases. We …

Sex differences in autoimmune disease | Nature Immunology Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting∼
1% of the adult population worldwide, with an estimated heritability of 60%. To identify …

Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes …

Genome searches for identifying susceptibility loci for the same complex disease often give
inconclusive or inconsistent results. Genome Search Meta‐analysis (GSMA) is an …

Candidate-gene association studies in rheumatoid arthritis (RA) have lead to encouraging
yet apparently inconsistent results. One explanation for the inconsistency is insufficient …

Gene-gene and gene-environment interactions are key features in the development of
rheumatoid arthritis (RA) and other complex diseases. The aim of this study was to use and …

Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …