Anti-TNF agents and new biological agents (Vedolizumab and Ustekinumab) in the prevention and treatment of postoperative recurrence after surgery in Crohn's …

JP Gisbert, M Chaparro - Drugs, 2023 - Springer
Surgery for Crohn's disease (CD) is not curative, as postoperative recurrence (POR) after
ileocolonic resection is the rule in the absence of prophylactic treatment. In the present …

Active margins, plexitis, and granulomas increase postoperative Crohn's recurrence: systematic review and meta-analysis

P Tandon, G Malhi, D Abdali, E Pogue… - Clinical …, 2021 - Elsevier
Background & Aims Rates of postoperative Crohn's disease recurrence remain high,
although the ability to predict this risk of recurrence remains limited. As such, we aimed to …

Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn “der Deutschen Gesellschaft für Gastroenterologie, Verdauungs-und Stoffwechselkrankheiten …

A Sturm, R Atreya, D Bettenworth… - Zeitschrift für …, 2022 - thieme-connect.com
Im Jahr 2019 wurden etwa 25 500 Patient* innen mit M. Crohn im Krankenhaus stationär
behandelt [1]. Meistens tritt die Erkrankung in der Adoleszenz und im jungen …

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence

S Khaloian, E Rath, N Hammoudi, E Gleisinger… - Gut, 2020 - gut.bmj.com
Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases
and impaired PC function contributes to the ileal pathogenesis of Crohn's disease (CD). PCs …

Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model

A Buisson, H Sokol, N Hammoudi, X Treton, M Nachury… - Gut, 2023 - gut.bmj.com
Objective We used the postoperative recurrence model to better understand the role of
adherent and invasive Escherichia coli (AIEC) bacteria in Crohn's disease (CD), taking …

Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn's disease

H Sokol, L Brot, C Stefanescu, C Auzolle, N Barnich… - Gut, 2020 - gut.bmj.com
Objective Following ileal resection for Crohn's disease (CD), recurrence is very frequent.
Although several clinical risk factors of recurrence have been identified, predicting relapse …

Endoscopic postoperative recurrence in Crohn's disease after curative ileocecal resection with early prophylaxis by anti-TNF, vedolizumab or ustekinumab: a real …

H Yanai, A Kagramanova, O Knyazev… - Journal of Crohn's …, 2022 - academic.oup.com
Background Endoscopic-post-operative-recurrence [ePOR] in Crohn's disease [CD] after
ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early …

Postoperative endoscopic recurrence on the neoterminal ileum but not on the anastomosis is mainly driving long-term outcomes in Crohn's disease

N Hammoudi, C Auzolle, MLT Minh… - Official journal of the …, 2020 - journals.lww.com
METHODS: The REMIND group conducted a prospective multicenter study. Patients
operated for ileal or ileocolonic CD were included. An ileocolonoscopy was performed 6 …

[HTML][HTML] Role of extended mesenteric excision in postoperative recurrence of Crohn's colitis: A single-center study

Y Zhu, W Qian, L Huang, Y Xu, Z Guo… - Clinical and …, 2021 - journals.lww.com
METHODS: Patients with CC who underwent colorectal resection between January 2000
and December 2018 were reviewed, and the data were gathered from a prospectively …

Risk of acute arterial events associated with treatment of inflammatory bowel diseases: nationwide French cohort study

J Kirchgesner, NN Andersen, F Carrat, T Jess… - Gut, 2020 - gut.bmj.com
Objective Patients with IBD are at increased risk of acute arterial events. Antitumour necrosis
factor (TNF) agents and thiopurines may, via their anti-inflammatory properties, lower the risk …