Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

Biochemical markers of bone turnover provide clinically useful evidence of the normal and
pathologic processes that reflect bone cell activity in the skeleton. Understanding the …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …

YKL-40, a 40-kDa secreted glycoprotein, with its gene located on chromosome 1q32. 1, is
produced by cancer cells and inflammatory cells and has a role in inflammation, cell …

PURPOSE: We investigated the efficacy and safety of degarelix treatment and the effects of
switching from leuprolide to degarelix in an ongoing extension study with a median 27.5 …

Validated biomarkers for patients suffering from gliomas are urgently needed for
standardizing measurements of the effects of treatment in daily clinical practice and trials …

YKL-40 is a heparin-and chitin-binding glycoprotein that belongs to the family of glycosyl
hydrolases but lacks enzymatic properties. It affects different (patho) physiological …

Since Huggins and Hodges demonstrated the responsiveness of prostate cancer to
androgen deprivation therapy (ADT), androgen‐suppressing strategies have formed the …

Abstract Chitinase 3‐like 1 (CHI3L1) is a secreted glycoprotein that has pleiotropic activity in
aggressive cancers. In our study, we examined the expression and function of CHI3L1 in …