CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is caused by a single genetic mutation and is amenable to predictive genetic testing, with …
JS Paulsen - Current neurology and neuroscience reports, 2011 - Springer
Cognition has been well characterized in the various stages of Huntington disease (HD) as well as in the prodrome before the motor diagnosis is given. Although the clinical diagnosis …
PC Nopoulos - Dialogues in clinical neuroscience, 2016 - Taylor & Francis
Huntington disease (HD) is an autosomal dominant, neurodegenerative disorder with a primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a …
Y Zhang, JD Long, JA Mills, JH Warner… - American Journal of …, 2011 - Wiley Online Library
The identification of clinical and biological markers of disease in persons at risk for Huntington disease (HD) has increased in efforts to better quantify and characterize the …
A Johnen, M Bertoux - Frontiers in neurology, 2019 - frontiersin.org
Behavioral variant frontotemporal dementia (bvFTD) is the second leading cognitive disorder caused by neurodegeneration in patients under 65 years of age. Characterized by …
R Ghosh, SJ Tabrizi - Handbook of clinical neurology, 2018 - Elsevier
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal- dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive …
SD Süssmuth, S Haider… - British journal of …, 2015 - Wiley Online Library
Aims Selisistat, a selective SirT1 inhibitor is being developed as a potentially disease‐ modifying therapeutic for Huntington's disease (HD). This was the first study of selisistat in …
EA Epping, JI Kim, D Craufurd… - American Journal of …, 2016 - Am Psychiatric Assoc
Objective: Psychiatric symptoms are a significant aspect of Huntington's disease, an inherited neurodegenerative illness. The presentation of these symptoms is highly variable …
Neurocognitive impairment in Huntington's disease (HD) frequently includes deficits in emotion recognition, and recent studies have also provided evidence for deficits in theory of …