Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Cognition has been well characterized in the various stages of Huntington disease (HD) as
well as in the prodrome before the motor diagnosis is given. Although the clinical diagnosis …

Huntington disease (HD) is an autosomal dominant, neurodegenerative disorder with a
primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a …

The identification of clinical and biological markers of disease in persons at risk for
Huntington disease (HD) has increased in efforts to better quantify and characterize the …

Behavioral variant frontotemporal dementia (bvFTD) is the second leading cognitive
disorder caused by neurodegeneration in patients under 65 years of age. Characterized by …

Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-
dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive …

Aims Selisistat, a selective SirT1 inhibitor is being developed as a potentially disease‐
modifying therapeutic for Huntington's disease (HD). This was the first study of selisistat in …

Objective: Psychiatric symptoms are a significant aspect of Huntington's disease, an
inherited neurodegenerative illness. The presentation of these symptoms is highly variable …

Neurocognitive impairment in Huntington's disease (HD) frequently includes deficits in
emotion recognition, and recent studies have also provided evidence for deficits in theory of …