Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors

Y Abdou, A Goudarzi, JX Yu, S Upadhaya… - NPJ Breast …, 2022 - nature.com
The development of immunotherapy agents has revolutionized the field of oncology. The
only FDA-approved immunotherapeutic approach in breast cancer consists of immune …

[HTML][HTML] Therapeutic vaccines for breast cancer: Has the time finally come?

C Corti, PPMB Giachetti, AMM Eggermont… - European Journal of …, 2022 - Elsevier
The ability to exploit the immune system as a weapon against cancer has revolutionised the
treatment of cancer patients, especially through immune checkpoint inhibitors (ICIs) …

[HTML][HTML] HER2-low breast cancers: incidence, HER2 staining patterns, clinicopathologic features, MammaPrint and BluePrint genomic profiles

H Zhang, H Katerji, BM Turner, W Audeh, DG Hicks - Modern Pathology, 2022 - Elsevier
Recently, clinical trials have demonstrated promising efficacy for novel HER2-targeted
therapies in HER2-low breast cancers, raising the prospect of including a HER2-low …

Immunotherapy for metastatic triple negative breast cancer: current paradigm and future approaches

V Geurts, M Kok - Current Treatment Options in Oncology, 2023 - Springer
Opinion statement In approximately 15–20% of the patients diagnosed with breast cancer, it
comprises the triple negative (TN) subtype, which until recently lacked targets for specific …

HER2-low breast cancers: new opportunities and challenges

H Zhang, H Katerji, BM Turner… - American journal of …, 2022 - academic.oup.com
Objectives Recent clinical trials have demonstrated significant clinical benefits from novel
therapeutic compounds in breast cancer patient with human epidermal growth factor …

Cancer vaccines for triple-negative breast cancer: a systematic review

M Hosseini, S Seyedpour, B Khodaei, AH Loghman… - Vaccines, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest
outcomes, and is associated with a high risk of relapse and metastasis. The treatment …

Tumor vaccines: Unleashing the power of the immune system to fight cancer

D Liu, X Che, X Wang, C Ma, G Wu - Pharmaceuticals, 2023 - mdpi.com
This comprehensive review delves into the rapidly evolving arena of cancer vaccines.
Initially, we examine the intricate constitution of the tumor microenvironment (TME), a …

MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer

MM Williams, JL Christenson, KI O'Neill, SA Hafeez… - NPJ Breast …, 2021 - nature.com
Many immune suppressive mechanisms utilized by triple negative breast cancer (TNBC) are
regulated by oncogenic epithelial-to-mesenchymal transition (EMT). How TNBC EMT …

Pathogenesis and potential therapeutic targets for triple-negative breast cancer

CJ Li, YDT Tzeng, YH Chiu, HY Lin, MF Hou, PY Chu - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer emergencies have become a rapidly evolving field in
medicine during the last ten years. Carcinogenesis is a multiparametric process that …

Immunotherapy: Constructive Approach for Breast Cancer Treatment

U Anayyat, F Ahad, TA Muluh, SAA Zaidi… - … Cancer: Targets and …, 2023 - Taylor & Francis
A novel and rapid therapeutic approach is the treatment of human breast cancer by
enhancing the host's immune system. In initial findings, program death one (PD-1) and …