The increasing resistance of malaria to drugs raise the need to new antimalarial agents.
Antiplasmodial herbs and their active compounds are the most promising source the new …

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for
chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association …

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant
of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are …

Plasmodium falciparum resistance to the former first-line antimalarials chloroquine and
sulfadoxine/pyrimethamine has reached critically high levels in many malaria-endemic …

Background. Artemisinin resistance, a long parasite clearance half-life in response to
artemisinin, has been described in patients with Plasmodium falciparum malaria in …

Changing treatment practices may be selecting for changes in the drug sensitivity of malaria
parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated …

Access to effective antimalarial therapy has increased dramatically. As malaria-endemic
countries begin to use artemisinin-based combination therapy (ACT) to treat malaria …

Background Usage of chloroquine was discontinued from the treatment of Plasmodium
falciparum infection in almost all endemic regions because of global spread of resistant …

In vitro antimalarial activity tests play a pivotal role in malaria drug research or for monitoring
drug resistance in field isolates. We applied two isotopic tests, two enzyme-linked …

Background As a result of widespread chloroquine and sulphadoxine-pyrimethamine
resistance, artemisinin-based combination therapy (ACT)(which includes artemether …