The early immune response to HIV-1 infection is likely to be an important factor in
determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies …

Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …

Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …

In progressive viral infection, antiviral T cell function is impaired by poorly understood
mechanisms. Here we report that the inhibitory immunoregulatory receptor CTLA-4 was …

Early immunological events during acute HIV infection are thought to fundamentally
influence long-term disease outcome. Whereas the contribution of HIV-specific CD8 T cell …

HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …

Abstract The adenovirus type 5 (Ad5)-based vaccine developed by Merck failed to either
prevent HIV-1 infection or suppress viral load in subsequently infected subjects in the STEP …

Functional defects in cytotoxic CD8+ T cell responses arise in chronic human viral infections,
but the mechanisms involved are not well understood. In mice, CD4 cell-mediated …

Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral
load to clinically undetectable levels, viral rebound inevitably occurs once ART is …

Thirty years after the identification of HIV, a cure for HIV infection is still to be achieved.
Advances of combined antiretroviral therapy (cART) in recent years have transformed HIV …