PET radiotracers and fluorescent probes for imaging human carbonic anhydrase IX and XII in hypoxic tumors
Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …
diagnosis, biomedical oncologic research, and drug development process, which include …
[HTML][HTML] Tumor associated carbonic anhydrase inhibitors: rational approaches, design strategies, structure activity relationship and mechanistic insights
The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …
therapeutic targets has urged rigorous research into the development of potent and selective …
Resveratrol analogues as dual inhibitors of monoamine oxidase b and carbonic anhydrase vii: a new multi-target combination for neurodegenerative diseases?
Neurodegenerative diseases (NDs) are described as multifactorial and progressive
syndromes with compromised cognitive and behavioral functions. The multi-target-directed …
syndromes with compromised cognitive and behavioral functions. The multi-target-directed …
Coumarin-pyrazoline hybrids as selective inhibitors of the tumor-associated carbonic anhydrase IX and XII
A Redij, S Carradori, A Petreni… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Aim: Human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are validated
antitumor/antimetastatic drug and tumor imaging targets with sulfonamide inhibitors and …
antitumor/antimetastatic drug and tumor imaging targets with sulfonamide inhibitors and …
Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and …
The involvement of human carbonic anhydrase (hCA) IX/XII in the pathogenesis and
progression of many types of cancer is well acknowledged, and more recently human …
progression of many types of cancer is well acknowledged, and more recently human …
Coumarin and piperazine conjugates as selective inhibitors of the tumor-associated carbonic anhydrase IX and XII isoforms
A Sethi, S Munagalasetty, M Arifuddin… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Background: Carbonic Anhydrases (CAs) are a family of metalloenzymes that catalyze the
reversible interconversion of CO2 and water to bicarbonate and proton. CA isoforms I, II, IX …
reversible interconversion of CO2 and water to bicarbonate and proton. CA isoforms I, II, IX …
Coumaryl‐sulfonamide moiety: Unraveling their synthetic strategy and specificity toward hCA IX/XII, facilitating anticancer drug development
Currently, cancer is the most grieving threat to society. The cancer‐related death rate has
had an ascending trend, despite the implementation of numerous treatment strategies or the …
had an ascending trend, despite the implementation of numerous treatment strategies or the …
Synthesis and investigation of selective human carbonic anhydrase IX, XII inhibitors using coumarins bearing a sulfonamide or biotin moiety
The role of carbonic anhydrases isoforms (CAs) IX and XII in the pathogenesis and
progression of many types of solid tumors is well known. In this context, selective CA …
progression of many types of solid tumors is well known. In this context, selective CA …
Synthesis of Chromene-linked Bis-indole Derivatives as Selective Tumor-associated Carbonic Anhydrase IX Inhibitors
Background Sulfonamide derivatives are well-reported hCA IX inhibitors; however, they
inhibit all types of hCA without any selectivity, leading to severe adverse effects. Hence …
inhibit all types of hCA without any selectivity, leading to severe adverse effects. Hence …