The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology
Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …
phenotypes has become increasingly possible due to advances in culturing techniques …
Physiological limitations and opportunities in microbial metabolic engineering
J Montaño López, L Duran, JL Avalos - Nature Reviews Microbiology, 2022 - nature.com
Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …
of the transportation and chemical manufacturing sectors. The field has already developed …
Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
Experimental design, population dynamics, and diversity in microbial experimental evolution
In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …
species, which can be monitored in real time. Despite the current popularity of such …
Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast
ML Skjoedt, T Snoek, KR Kildegaard… - Nature chemical …, 2016 - nature.com
Whole-cell biocatalysts have proven a tractable path toward sustainable production of bulk
and fine chemicals. Yet the screening of libraries of cellular designs to identify best …
and fine chemicals. Yet the screening of libraries of cellular designs to identify best …
Acetate as a potential feedstock for the production of value-added chemicals: metabolism and applications
Acetate is regarded as a promising carbon feedstock in biological production owing to its
possible derivation from C 1 gases such as CO, CO 2 and methane. To best use of acetate …
possible derivation from C 1 gases such as CO, CO 2 and methane. To best use of acetate …
[HTML][HTML] Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production
Highlights•Recent technological advances amplify the power of yeast evolutionary
engineering.•Dynamic selection regimes can mitigate phenotypic trade-off …
engineering.•Dynamic selection regimes can mitigate phenotypic trade-off …
[HTML][HTML] Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine
Microbial fermentation of renewable feedstocks into plastic monomers can decrease our
fossil dependence and reduce global CO 2 emissions. 3-Hydroxypropionic acid (3HP) is a …
fossil dependence and reduce global CO 2 emissions. 3-Hydroxypropionic acid (3HP) is a …
Yeast's balancing act between ethanol and glycerol production in low‐alcohol wines
Alcohol is fundamental to the character of wine, yet too much can put a wine off‐balance. A
wine is regarded to be well balanced if its alcoholic strength, acidity, sweetness, fruitiness …
wine is regarded to be well balanced if its alcoholic strength, acidity, sweetness, fruitiness …
Biobased organic acids production by metabolically engineered microorganisms
Highlights•The use of inexpensive carbon sources is urgently needed for citric acid
production.•Low-pH process benefits lactic acid production.•Different strains and processes …
production.•Low-pH process benefits lactic acid production.•Different strains and processes …