For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic
levels, however, challenges such as rapid renal clearance, degradation or non-specific …

Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

There is currently an unmet need for better biomarkers across the spectrum of renal
diseases. In this paper, we revisit the role of beta-2 microglobulin (β2M) as a biomarker in …

Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and
transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

Urinary exosome-like vesicles (ELVs) are a heterogenous mixture (diameter 40–200 nm)
containing vesicles shed from all segments of the nephron including glomerular podocytes …

Abstract Background: Cadmium (Cd) is abundantly documented as a metal mainly affecting
tubular function both in workers and in the general population indirectly exposed via the …