Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling
network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is …

Highlights•The surfaceome is a complex signaling gateway enabling extracellular
interactions.•Surfaceome PPI's are modulated by proteoform composition, abundance and …

Many membrane proteins form functional complexes that are either homo-or hetero-
oligomeric. However, it is challenging to characterize membrane protein oligomerization in …

Receptor tyrosine kinases (RTKs) are the essential regulators of cell signal transduction
pathways and play important roles in biological processes. RTK dimerization is generally …

The study of membrane proteins is undergoing a golden era, and we are gaining
unprecedented knowledge on how this key group of proteins works. However, we still have …

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that is
upregulated in aggressive triple-negative breast cancer (TNBC). Ligands such as EGF, TGF …

Receptor tyrosine kinases (RTKs) are known to perform versatile roles in disease
landscapes, which determine the fate of the cell. Although much has been discussed from …

Cell surface receptor oligomerization is an attractive target process for drug screening.
However, simple but reliable (and thus high‐throughput) visualization methods for receptor …

A universal method to measure the binding affinities of antibody drugs towards their targets
on the surface of living cells was developed based on atomic force microscopy (AFM) …