Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention

CL Holmes, OR Albin, HLT Mobley… - Nature Reviews …, 2024 - nature.com
Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing
in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune …

Quantitative dose-response analysis untangles host bottlenecks to enteric infection

IW Campbell, K Hullahalli, JR Turner… - Nature …, 2023 - nature.com
Host bottlenecks prevent many infections before the onset of disease by eliminating
invading pathogens. By monitoring the diversity of a barcoded population of the diarrhea …

Both pathogen and host dynamically adapt pH responses along the intestinal tract during enteric bacterial infection

SE Woodward, LMP Neufeld, J Peña-Díaz, W Feng… - PLoS …, 2024 - journals.plos.org
Enteric pathogens navigate distinct regional microenvironments within the intestine that cue
important adaptive behaviors. We investigated the response of Citrobacter rodentium, a …

Association of proton pump inhibitor use with risk of acquiring drug-resistant Enterobacterales

RPJ Willems, MC Schut, AM Kaiser, TH Groot… - JAMA network …, 2023 - jamanetwork.com
Importance Proton-pump inhibitors (PPIs) have been associated with the risk of colonization
with drug-resistant bacteria; however, possible confounding by lifestyle-associated factors …

Temporal and spatial dynamics of Listeria monocytogenes central nervous system infection in mice

V Chevée, K Hullahalli, KG Dailey… - Proceedings of the …, 2024 - National Acad Sciences
Listeria monocytogenes is a bacterial pathogen that can cause life-threatening central
nervous system (CNS) infections. While mechanisms by which L. monocytogenes and other …

Post-infectious irritable bowel syndrome after intercontinental travel: a prospective multicentre study

J Chan, N van Best, M Ward, MS Arcilla… - Journal of travel …, 2023 - academic.oup.com
By longitudinally following a large cohort of intercontinental travellers, this study highlights
the importance of considering multiple risk factors to comprehend post-infectious irritable …

Quorum sensing modulates bacterial virulence and colonization dynamics of the gastrointestinal pathogen Citrobacter rodentium

J Peña-Díaz, SE Woodward, A Creus-Cuadros… - Gut …, 2023 - Taylor & Francis
Quorum Sensing (QS) is a form of cell-to-cell communication that enables bacteria to modify
behavior according to their population density. While QS has been proposed as a potential …

Spatial structure facilitates evolutionary rescue by cost-free drug resistance

C Fruet, EL Müller, C Loverdo, AF Bitbol - arXiv preprint arXiv:2409.07377, 2024 - arxiv.org
Bacterial populations often have complex spatial structures, which can impact their
evolution. Here, we study how spatial structure affects the evolution of antibiotic resistance in …

Inducible transposon mutagenesis for genome-scale forward genetics

DW Basta, IW Campbell, EJ Sullivan, JA Hotinger… - bioRxiv, 2024 - biorxiv.org
Transposon insertion sequencing (Tn-seq) is a powerful method for genome-scale
functional genetics in bacteria. However, its effectiveness is often limited by a lack of mutant …

Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung

CL Holmes, KG Dailey, K Hullahalli, AE Wilcox… - bioRxiv, 2024 - biorxiv.org
Bacteremia, a leading cause of death, generally arises after bacteria establish infection in a
particular tissue and transit to secondary sites. Studying dissemination from primary sites by …