An insight into novel therapeutic potentials of taxifolin

Y Liu, X Shi, Y Tian, S Zhai, Y Liu, Z Xiong… - Frontiers in …, 2023 - frontiersin.org
Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees,
which is often found in foods such as onions and olive oil, and is also used in commercial …

Unveiling the therapeutic potential of Taxifolin in Cancer: From molecular mechanisms to immune modulation and synergistic combinations

NH Sarg, FH Hersi, DM Zaher, AO Hamouda… - Phytomedicine, 2024 - Elsevier
Background Taxifolin (TAX), a flavonoid abundant in various medicinal plants, has gained
attention for its multifaceted role in cancer therapy and cytoprotection against chemotherapy …

Syringic acid protects against thioacetamide-induced hepatic encephalopathy: behavioral, biochemical, and molecular evidence

IF Okkay, U Okkay, OL Gundogdu, C Bayram… - Neuroscience …, 2022 - Elsevier
The objective of this study was to elucidate the effects of syringic acid on thioacetamide-
induced hepatic encephalopathy which is a complex serious syndrome with …

Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease

I Ferah Okkay, U Okkay, B Cicek, A Yilmaz… - Molecular Biology …, 2021 - Springer
Background This study was designed to investigate the neuroprotective effects of bromelain,
which is known to have anti-oxidant and anti-inflammatory properties, against the …

Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐induced peripheral …

WS Abd Elaleem, HR Ghaiad, MA Abd Elmawla… - …, 2024 - Wiley Online Library
Paclitaxel (PTX)‐induced peripheral neuropathy (PIPN) is a disabling side effect of PTX,
which adversely affects the life quality of cancer patients. Flavonoids such as hesperidin …

Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study

U Okkay, I Ferah Okkay, IC Aydin… - … and ocular toxicology, 2021 - Taylor & Francis
Aim: Cisplatin is a widely used and highly effective anti-cancer agent and one of the limiting
side effects of cisplatin is ocular toxicity. Achillea millefolium, also known as yarrow, is a …

Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation

I Ferah Okkay, U Okkay, C Bayram… - Drug and chemical …, 2023 - Taylor & Francis
The aim of this study was to investigate the molecular, biochemical, and histopathological
effects of bromelain, which has antioxidant and anti-inflammatory properties, against …

Taxifolin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like mouse model via regulating cytoplasmic phospholipase A2 and PPAR-γ …

T Di, C Zhai, J Zhao, Y Wang, Z Chen, P Li - International …, 2021 - Elsevier
Psoriasis is a skin disease with autoimmune tendency, and taxifolin is an effective flavonoid
with anti-inflammatory activity. It has been reported that taxifolin alleviates psoriatic …

Protective effects of arbutin against doxorubicin-induced cardiac damage

O Birdal, I Ferah Okkay, U Okkay, C Bayram… - Molecular Biology …, 2024 - Springer
Background Doxorubicin is an effective antineoplastic agent but has limited clinical
application because of its cumulative toxicities, including cardiotoxicity. Cardiotoxicity …

Pharmacological investigation of taxifolin for its therapeutic potential in depression

M Mir, A Khan, A Khan - Heliyon, 2024 - cell.com
The current study aimed to investigate the influence of taxifolin on depression symptoms
alleviation in Male Sprague-Dawley rats by targeting underlying pathways of depression …