Nanodisc‐Mediated Conversion of Virustatic Antiviral Antibody to Disrupt Virus Envelope in Infected Cells
Many antibody‐based antivirals, including broadly neutralizing antibodies (bnAbs) against
various influenza virus strains, suffer from limited potency. A booster of the antiviral activity of …
various influenza virus strains, suffer from limited potency. A booster of the antiviral activity of …
Conversion of Host Cell Receptor into Virus Destructor by Immunodisc to Neutralize Diverse SARS‐CoV‐2 Variants
The decreasing efficacy of antiviral drugs due to viral mutations highlights the challenge of
developing a single agent targeting multiple strains. Using host cell viral receptors as …
developing a single agent targeting multiple strains. Using host cell viral receptors as …
Bifunctional hetero di-disc for broad-spectrum influenza neutralization
S Moon, J Chung, Y Kim, C Hong, S Kim… - … , Biology and Medicine, 2022 - Elsevier
Nanodiscs containing sialic acid, which binds the hemagglutinin of the influenza virus,
rupture the viral envelope and entrap viral ribonucleoproteins in the endolysosome. While …
rupture the viral envelope and entrap viral ribonucleoproteins in the endolysosome. While …