Signaling pathways and intervention for therapy of type 2 diabetes mellitus

R Cao, H Tian, Y Zhang, G Liu, H Xu, G Rao… - MedComm, 2023 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic
disorders worldwide and is a strong contributor for a broad range of comorbidities, including …

Unique features of β‐cell metabolism are lost in type 2 diabetes

F Muñoz, M Fex, T Moritz, H Mulder… - Acta …, 2024 - Wiley Online Library
Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as
they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose …

PPM1G promotes autophagy and progression of pancreatic cancer via upregulating HMGB1

M Song, M Xu, Q Zhang, T Fan, J Xu, C Hang… - Cellular …, 2024 - Elsevier
Pancreatic cancer remains one of the most aggressive and lethal malignancies worldwide,
with a dismal 5-year relative survival rates of only 12%. Therefore, it is urgent to discover the …