The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology
Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …
Epithelial–mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and
many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer …
many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer …
Drug resistance in non-small cell lung cancer: a potential for NOTCH targeting?
Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …
Mechanisms of resistance to chemotherapy in non-small cell lung cancer
HY Min, HY Lee - Archives of pharmacal research, 2021 - Springer
Non-small cell lung cancer (NSCLC), which represents 80–85% of lung cancer cases, is one
of the leading causes of human death worldwide. The majority of patients undergo an …
of the leading causes of human death worldwide. The majority of patients undergo an …
Understanding and targeting resistance mechanisms in cancer
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …
practice, which is one of the major causes of treatment failure and poor patient survival. The …
Reversal of multidrug resistance in cancer by multi-functional flavonoids
Q Ye, K Liu, Q Shen, Q Li, J Hao, F Han… - Frontiers in …, 2019 - frontiersin.org
Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one
of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have …
of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have …
Exploring the crosstalk between inflammation and epithelial‐mesenchymal transition in cancer
I Chattopadhyay, R Ambati… - Mediators of …, 2021 - Wiley Online Library
Tumor cells undergo invasion and metastasis through epithelial‐to‐mesenchymal cell
transition (EMT) by activation of alterations in extracellular matrix (ECM) protein‐encoding …
transition (EMT) by activation of alterations in extracellular matrix (ECM) protein‐encoding …
Cancer-associated fibroblasts induce epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer via CXCL12/CXCR4 axis
F Zhang, J Cui, H Gao, H Yu, F Gao, J Chen… - Future …, 2020 - Taylor & Francis
Aim: Cancer-associated fibroblasts (CAFs) are closely related to epithelial-mesenchymal
transition (EMT) and chemoresistance in various cancers. Patients & methods: Experiments …
transition (EMT) and chemoresistance in various cancers. Patients & methods: Experiments …
HOXD-AS1 promotes the epithelial to mesenchymal transition of ovarian cancer cells by regulating miR-186-5p and PIK3R3
Background Epithelial ovarian cancer (EOC) is one of the most malignant gynecological
tumors worldwide. Deregulation of long non-coding RNAs (lncRNAs) has been implicated in …
tumors worldwide. Deregulation of long non-coding RNAs (lncRNAs) has been implicated in …