[HTML][HTML] Zinc as a therapeutic agent in bone regeneration

JP O'Connor, D Kanjilal, M Teitelbaum, SS Lin… - Materials, 2020 - mdpi.com
Zinc is an essential mineral that is required for normal skeletal growth and bone
homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However …

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

S Bose, G Fielding, S Tarafder… - Trends in …, 2013 - cell.com
General trends in synthetic bone grafting materials are shifting towards approaches that can
illicit osteoinductive properties. Pharmacologics and biologics have been used in …

In vitro and in vivo studies on zinc-hydroxyapatite composites as novel biodegradable metal matrix composite for orthopedic applications

H Yang, X Qu, W Lin, C Wang, D Zhu, K Dai, Y Zheng - Acta biomaterialia, 2018 - Elsevier
Recent studies indicate that there is a great demand to optimize pure Zn with tunable
degradation rates and more desirable biocompatibility as orthopedic implants. Metal matrix …

Application of bioactive metal ions in the treatment of bone defects

S Li, Y Cui, H Liu, Y Tian, G Wang, Y Fan… - Journal of Materials …, 2022 - pubs.rsc.org
The treatment of bone defects is an important problem in clinical practice. The rapid
development of bone tissue engineering (BTE) may provide a new method for bone defect …

[HTML][HTML] 3D-Printed PCL/Zn scaffolds for bone regeneration with a dose-dependent effect on osteogenesis and osteoclastogenesis

S Wang, R Gu, F Wang, X Zhao, F Yang, Y Xu, F Yan… - Materials Today Bio, 2022 - Elsevier
Polycaprolactone (PCL) is a polymer material suitable for being prepared into porous
scaffolds used in bone tissue engineering, however, insufficient osteogenic ability and …

PCL/chitosan/Zn-doped nHA electrospun nanocomposite scaffold promotes adipose derived stem cells adhesion and proliferation

FM Ghorbani, B Kaffashi, P Shokrollahi… - Carbohydrate …, 2015 - Elsevier
Abstract Chitosan (Ch), and poly (ɛ-caprolactone)(PCL), widely used as biomaterials with
desirable properties for tissue engineering applications, were both blended with zinc-doped …

In situ generation of hydroxyapatite on biopolymer particles for fabrication of bone scaffolds owning bioactivity

P Feng, S Peng, C Shuai, C Gao, W Yang… - … applied materials & …, 2020 - ACS Publications
Hydroxyapatite (HAP) can endow a biopolymer scaffold with good bioactivity and
osteoconductive ability, while the interfacial bonding is fairly weak between HAP and …

Regulation of the biological functions of osteoblasts and bone formation by Zn-incorporated coating on microrough titanium

X Shen, Y Hu, G Xu, W Chen, K Xu, Q Ran… - … Applied Materials & …, 2014 - ACS Publications
To improve the biological performance of titanium implant, a series of Zn-incorporated
coatings were fabricated on the microrough titanium (Micro-Ti) via sol–gel method by spin …

Mechanical, biological, and antibacterial characteristics of plasma-sprayed (Sr, Zn) substituted hydroxyapatite coating

I Ullah, MA Siddiqui, H Liu, SK Kolawole… - ACS Biomaterials …, 2020 - ACS Publications
Implant-related infections are a major concern in total joint prostheses, occurring up to 3% in
operations. In this work, 5% Zn2+ was added in HA to offset bacterial activity and 5% Sr2+ …

Enhanced osteogenesis and angiogenesis of calcium phosphate cement incorporated with zinc silicate by synergy effect of zinc and silicon ions

T Lu, J Zhang, X Yuan, C Tang, X Wang… - Materials Science and …, 2021 - Elsevier
Calcium phosphate cement (CPC) with good injectability and osteoconductivity plays
important roles in bone grafting application. Much attention has been paid to achieve …