Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …

The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …

Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …

Production of new neurons in the adult hippocampus decreases with age; this decline may
underlie age-related cognitive impairment. Here we show that continuous depletion of the …

Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region
differentiate and proliferate into new neurons and other resident brain cells, is known to be …

What has become standard textbook knowledge over the last decade was a hotly debated
matter a decade earlier: the proposition that new neurons are generated in the adult …

The hormones and other physiological agents that mediate the effects of stress on the body
have protective and adaptive effects in the short run and yet can accelerate pathophysiology …

Aging causes changes in the hippocampus that may lead to cognitive decline in older
adults. In young animals, exercise increases hippocampal neurogenesis and improves …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …