Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …

Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by
impairments in social interaction and communication and restricted and repetitive …

Brain aging is associated with diminished circadian clock output and decreased expression
of the core clock proteins, which regulate many aspects of cellular biochemistry and …

The time when an event occurs can become part of autobiographical memories. In brain
structures that support such memories, a neural code should exist that represents when or …

The circadian system has pronounced influence on learning and memory, manifesting as
marked changes in memory acquisition and recall across the day. From a mechanistic …

Disturbance of the circadian system, manifested as disrupted daily rhythms of physiologic
parameters such as sleep, activity, and hormone secretion, has long been observed as a …

Although circadian rhythms in mammalian physiology and behavior are dependent upon a
biological clock in the suprachiasmatic nuclei (SCN) of the hypothalamus, the molecular …

The circadian clock is an endogenous, time-tracking system that directs multiple metabolic
and physiological functions required for homeostasis. The master or central clock located …

Psychiatric and neurodegenerative disorders, including intellectual disability, autism
spectrum disorders (ASD), schizophrenia (SZ), and Alzheimer's disease, pose an immense …

The time of day strongly influences adaptive behaviors like long-term memory, but the
correlating synaptic and molecular mechanisms remain unclear. The circadian clock …