Buprenorphine is an opioid that has a complex and unique pharmacology which provides
some advantages over other potent mu agonists. We review 12 reasons for considering …

Health care providers in the United States are facing challenges in selecting appropriate
medication for patients with acute and chronic pain in the midst of the current opioid crisis …

The current literature describes the possible risks for bone fracture in chronic analgesics
users. There are three main hypotheses that could explain the increased risk of fracture …

Background Chronic pain is associated with decreased quality of life and is one of the most
common reasons adults seek medical care, making treatment imperative for many aspects of …

Background The prevalence of chronic non‐cancer pain (CNCP) has increased dramatically
the past decades, which combined with indiscriminate use of prescribed opioids has …

Background and aims Neuropathic pain has been shown to be accompanied by cognitive
impairment, but the specific impact of postherpetic neuropathic pain on cognitive processes …

Opioids are pivotal therapeutics in the management of escalated chronic pain (moderate–
severe). In the last two decades, the increased prescription rate and the prolonged usage of …

Context Hypogonadism is a well-established consequence of opioid use. It has been
reported in both men and women, although more widely studied in men. Evidence …

Background: Sexual dysfunction and Opioid-Induced Sexual Hormone Deficiency (OPISHD)
have been associated with patients on long-term opioid pain therapy. There have been few …

This paper is the thirty-fourth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2011 …