Lymphangioleiomyomatosis (LAM) is a slowly progressive, low-grade, metastasising
neoplasm of women, characterised by infiltration of the lung parenchyma with abnormal …

Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …

Accurate cell type identification is a key and rate-limiting step in single-cell data analysis.
Single-cell references with comprehensive cell types, reproducible and functionally …

Organ-and body-scale cell atlases have the potential to transform our understanding of
human biology. To capture the variability present in the population, these atlases must …

Abstract mTORC1 is hyperactive in multiple cancer types,. Here, we performed integrative
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …

The human lung cellular portfolio, traditionally characterized by cellular morphology and
individual markers, is highly diverse, with over 40 cell types and a complex branching …

Lymphangioleiomyomatosis (LAM) is a rare disease affecting women, caused by somatic
mutations in the TSC1 or TSC2 genes, and driven by estrogen. Similar to many cancers, it is …

Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic
inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for …

Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder affecting almost all
organs with no sex predominance. TSC has an autosomal-dominant inheritance and is …