Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Green tea has been shown to have beneficial effects against cancer, obesity,
atherosclerosis, diabetes, bacterial and viral infections, and dental caries. The catechin (−) …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

ABSTRACT Introduction Type 1 diabetes (T1D) is an autoimmune disease in which pro-
inflammatory and cytotoxic signaling drive the death of the insulin-producing β cells. This …

Abstract Background Type 1 diabetes (T1D) is a complex autoimmune disorder whose
pathogenesis involves an intricate interplay between β cells of the pancreatic islet, other islet …

Glycerophospholipids are major components of cell membranes and consist of a glycerol
backbone esterified with one of over 30 unique fatty acids at each of the sn-1 and sn-2 …

Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked
to metabolic syndrome, with implications in the development of insulin resistance, pancreatic …

Abstract Background The Environmental Determinants of the Diabetes in the Young
(TEDDY) study has prospectively followed, from birth, children at increased genetic risk of …

Both calcium-independent phospholipase A2 beta (iPLA2β) and endoplasmic reticulum
(ER) stress regulate important pathophysiological processes including inflammation …