Background Recent advances in genomewide studies have revealed the abundance of long
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of
regulators of gene expression. lncRNAs exhibit several distinctive features that confer …

Long noncoding RNAs (lncRNAs) are key regulators of chromatin state, yet the nature and
sites of RNA-chromatin interaction are mostly unknown. Here we introduce Chromatin …

Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which
different combinations of genetic mutations may contribute to the phenotype. Using Rett …

To equalize X-chromosome dosages between the sexes, the female mammal inactivates
one of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Acetylation of the [var epsilon]-amino group of a lysine residue was first discovered with
histones in 1968, but the responsible enzymes, histone acetyltransferases and …

The long noncoding Xist RNA inactivates one X chromosome in the female mammal.
Current models posit that Xist induces silencing as it spreads along X and recruits Polycomb …

Once protein-coding, the X-inactivation center (Xic) is now dominated by large noncoding
RNAs (ncRNA). X chromosome inactivation (XCI) equalizes gene expression between …

Histone methylation regulates chromatin structure, transcription, and epigenetic state of the
cell. Histone methylation is dynamically regulated by histone methylases and demethylases …