The buildup of nonionic surfactants in the aqueous environment produces niosomes. The
usage of niosomes is becoming increasingly frequent due to their sustainability, low cost of …

The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

This study aimed at delivering intranasal zolmitriptan directly to the brain through
preparation of bilosomes incorporated into a mucoadhesive in situ gel with extended nasal …

Thymoquinone (TQ), a natural polyphenol, has been associated with various
pharmacological responses; however, low bioavailability of TQ limits its clinical application …

Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Introduction There is an unmet need to develop potent therapeutics against cancer with
minimal side effects and systemic toxicity. Thymol (TH) is an herbal medicine with anti …

Non-healing wounds impose huge cost on patients, healthcare, and society, which are
further fortified by biofilm formation and antimicrobial resistance (AMR) problems. Here …

Intranasal administration is a drug delivery approach to provide a non-invasive
pharmacological response in the central nervous system with relatively small peripheral side …