Lobular carcinoma in situ (LCIS) is a risk factor and a nonobligate precursor of breast
carcinoma. The relative risk of invasive carcinoma after classic LCIS diagnosis is …

Simple Summary Invasive lobular breast cancer (ILC) is a special type of breast cancer (BC)
that was first described in 1941. The diagnosis of ILC is made by microscopy of tumor …

Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

We have entered a transformative period in cancer prevention (including early detection).
Remarkable progress in precision medicine and immune-oncology, driven by extraordinary …

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer
(LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A …

Lobular neoplasia (LN) is an atypical proliferation of small, dyscohesive epithelial cells
within the terminal duct lobular unit (TDLU), with or without pagetoid extension and …

Purpose: Lobular carcinoma in situ (LCIS) is a preinvasive lesion of the breast. We sought to
define its genomic landscape, whether intralesion genetic heterogeneity is present in LCIS …

Prevention is an essential component of cancer eradication. Next-generation sequencing of
cancer genomes and epigenomes has defined large numbers of driver mutations and …

Loss of E-cadherin expression due to mutation of the CDH1 gene is a characteristic feature
of invasive lobular breast cancer (ILBC). Beta-catenin, which binds to the cytoplasmic …

The current histological classification of in‐situ and invasive lobular carcinomas (ILCs)
includes different morphological variants, some of which have been recently described. In …