Introduction: Drug discovery is the process through which potential new compounds are
identified by means of biology, chemistry, and pharmacology. Due to the high complexity of …

The complexity of orphan diseases, which are those that do not have an effective treatment,
together with the high dimensionality of the genetic data used for their analysis and the high …

We present the analysis of the defective genetic pathways of the Late-Onset Alzheimer's
Disease (LOAD) compared to the Mild Cognitive Impairment (MCI) and Healthy Controls …

Noise is a basic ingredient in data, since observed data are always contaminated by
unwanted deviations, ie, noise, which, in the case of overdetermined systems (with more …

In this research work, we introduce several novel methods to identify the defective pathways
in highly uncertain phenotype prediction problems. More specifically, we applied these …