Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

Anxiety disorders are the most common mental illness in the USA affecting 18% of the
population. The cause (s) of anxiety disorders is/are not completely clear, and research in …

The transcription factor erythroid 2-related factor 2 (Nrf2) and brain-derived neurotrophic
factor (BDNF) play a key role in depression. However, the molecular mechanisms …

Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia
from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice …

Abstract The transcription factor Keap1-Nrf2 system plays a key role in inflammation which is
involved in depression. We found lower expression of Keap1 and Nrf2 proteins in the …

Chronic stress is the major pathogenetic factor of human anxiety and depression. Zebrafish
(Danio rerio) have become a novel popular model species for neuroscience research and …

Depression is one of the most common mood disorders with a high rate of relapse.
Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived …