Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-
dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since …

The defining feature of the Gram-negative cell envelope is the presence of two cellular
membranes, with the specialized glycolipid lipopolysaccharide (LPS) exclusively found on …

Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded
products or pathogen activities often enables the activation of a subset of caspases. In most …

Inflammasomes are macromolecular complexes formed in response to pathogen‐
associated molecular patterns (PAMPs) and danger‐associated molecular patterns …

The innate immune response to lipopolysaccharide is essential for host defense against
Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is …

The gamma-interferon (IFNγ)-inducible guanylate-binding proteins (GBPs) promote host
defense against gram-negative cytosolic bacteria in part through the induction of an …