Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Supercritical anti-solvent (SAS) method is a solvent-free approach where supercritical
carbon dioxide (SC-CO 2) is used as anti-solvent and one can control the output particle …

In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …

This work presents the results of using tree-based models, including Gradient Boosting,
Extra Trees, and Random Forest, to model the solubility of hyoscine drug and solvent …

Solubility of pharmaceutical compounds in the supercritical carbon dioxide (sc-CO 2) is an
essential parameter in the development of the pharmaceutical industry. In this work, the …

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

The unique properties of supercritical fluids, in particular supercritical carbon dioxide (CO2),
provide numerous opportunities for the development of processes for pharmaceutical …

To estimate half-lives for novel fluoroethers, the GenX Exposure Study obtained two serum
measurements for per-and polyfluoroalkyl substances (PFAS) for 44 participants of age 12 …

Reducing the size of pharmaceutical particles is an approved way to enhance solubility and
bioavailability of a drug, leading to a decrease in the drug dose and its side effects. In this …