Multiple myeloma: signaling pathways and targeted therapy

Q Lu, D Yang, H Li, T Niu, A Tong - Molecular Biomedicine, 2024 - Springer
Multiple myeloma (MM) is the second most common hematological malignancy of plasma
cells, characterized by osteolytic bone lesions, anemia, hypercalcemia, renal failure, and the …

[HTML][HTML] Impact of Anti-CD38 Monoclonal Antibody Therapy on CD34+ Hematopoietic Stem Cell Mobilization, Collection, and Engraftment in Multiple Myeloma …

F Bigi, E Manzato, S Barbato, M Talarico, M Puppi… - Pharmaceuticals, 2024 - mdpi.com
This systematic review examines the available clinical data on CD34+ cell mobilization,
collection, and engraftment in multiple myeloma patients treated with the anti-CD38 …

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

T Facon, MA Dimopoulos, XP Leleu… - … England Journal of …, 2024 - Mass Medical Soc
Background Bortezomib, lenalidomide, and dexamethasone (VRd) is a preferred first-line
treatment option for patients with newly diagnosed multiple myeloma. Whether the addition …

Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem transplant for high-risk newly diagnosed myeloma

C Touzeau, A Perrot, C Hulin, S Manier, M Macro… - Blood, 2024 - ashpublications.org
High-risk (HR) cytogenetics are associated with poor outcomes in newly diagnosed multiple
myeloma (NDMM), and dedicated studies should address this difficult-to-treat population …

Multiple Myeloma: The Role of Autologous Stem Cell Transplantation in the Era of Immunotherapy

S Rocchi, BA Zannetti, G Marconi, F Lanza - Cells, 2024 - mdpi.com
Upfront high-dose therapy with melphalan (HDM) followed by autologous stem cell
transplantation (ASCT) has established itself as a core treatment for newly diagnosed …

Final analysis of a phase II trial of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma without transplant

BA Derman, J Cooperrider, J Rosenblatt… - Blood Cancer …, 2024 - nature.com
We evaluated the efficacy and safety of 24 cycles of Dara in combination with carfilzomib (K),
lenalidomide (R), and dexamethasone (d) without autologous stem cell transplant (ASCT) in …

Diagnosis and initial treatment of transplant‐eligible high‐risk myeloma patients: a British Society for Haematology/UK Myeloma Society Good Practice Paper

M Kaiser, G Pratt, C Bygrave, K Bowles… - British Journal of …, 2024 - Wiley Online Library
Summary This Good Practice Paper provides recommendations for the diagnosis and initial
management of transplant‐eligible high‐risk myeloma patients. It describes recent updates …

Isatuximab, carfilzomib, lenalidomide, and dexamethasone in patients with newly diagnosed, transplantation-eligible multiple myeloma (SKylaRk): a single-arm …

E O'Donnell, C Mo, AJ Yee, O Nadeem… - The Lancet …, 2024 - thelancet.com
Background Isatuximab is a CD38 monoclonal antibody approved for relapsed or refractory
multiple myeloma. We aimed to evaluate the addition of isatuximab to weekly carfilzomib (K) …

Long term responders in frontline multiple myeloma—exception vs expectation of the modern era

M Baljevic, DW Sborov, SK Kumar - Blood cancer journal, 2024 - nature.com
Described as mollities ossium in 1844, the first reported case of a patient with multiple
myeloma (MM) was a 39 year-old-woman treated with an infusion of orange-peel, rhubarb …

Upfront or Deferred Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma in the Era of Triplet and Quadruplet Induction and Minimal Residual …

CC Mo, MA Hartley-Brown, S Midha, PG Richardson - Cancers, 2023 - mdpi.com
Simple Summary Patients who are diagnosed with multiple myeloma are given an initial
sequence of treatments that usually, for those who are young and fit enough, includes high …