This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …

Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to
pulmonary pathologies, including lung edema and lung injury. However, in pulmonary …

Background: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced
hypertension. The recognition that Ca2+ signaling in endothelial cells promotes vasodilation …

Background: Ca2+ signals in smooth muscle cells (SMCs) contribute to vascular resistance
and control blood pressure. Increased vascular resistance in hypertension has been …

Abstract Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in
pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the …

Endothelial cells line all blood vessels and are critical regulators of vascular tone. In
hypertension, disruption of endothelial function alters the release of endothelial-derived …