Status epilepticus: pathophysiology and management in adults

JWY Chen, CG Wasterlain - The Lancet Neurology, 2006 - thelancet.com
Summary As in Clark and Prout's classic work, we identify three phases of generalised
convulsive status epilepticus, which we call impending, established, and subtle. We review …

Treatment of refractory status epilepticus: literature review and a proposed protocol

NS Abend, DJ Dlugos - Pediatric neurology, 2008 - Elsevier
Refractory status epilepticus describes continuing seizures despite adequate initial
pharmacologic treatment. This situation is common in children, but few data are available to …

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

T Engel, R Gomez‐Villafuertes, K Tanaka… - The FASEB …, 2012 - Wiley Online Library
Prolonged seizures [status epilepticus (SE)] constitute a neurological emergency that can
permanently damage the brain. SE results from a failure of the normal mechanisms to …

Advances in the pathophysiology of status epilepticus

JWY Chen, DE Naylor… - Acta Neurologica …, 2007 - Wiley Online Library
Status epilepticus (SE) describes an enduring epileptic state during which seizures are
unremitting and tend to be self‐perpetuating. We describe the clinical phases of generalized …

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs

CG Wasterlain, JWY Chen - Epilepsia, 2008 - Wiley Online Library
We review recent advances in our understanding and treatment of status epilepticus (SE).
Repeated seizures cause an internalization of γ‐aminobutyric acid (GABA) A receptors …

The uncommon causes of status epilepticus: a systematic review

RYL Tan, A Neligan, SD Shorvon - Epilepsy research, 2010 - Elsevier
This paper reports the first systematic review of uncommon causes of status epilepticus
reported in the literature between 1990 and 2008. Uncommon causes are defined as those …

The ketogenic diet for the treatment of pediatric status epilepticus

SE O'Connor, C Richardson, WH Trescher, DL Byler… - Pediatric …, 2014 - Elsevier
Background Refractory status epilepticus carries a high risk of morbidity and mortality for
children. Traditional treatment of status epilepticus consists of multiple anticonvulsant drugs …

Management of prolonged seizures and status epilepticus in childhood: a systematic review

K Sofou, R Kristjánsdottir… - Journal of child …, 2009 - journals.sagepub.com
Pediatric prolonged seizures and status epilepticus are medical emergencies necessitating
immediate life-support and seizure-control measures. A systematic review of published data …

Treatment of status epilepticus with ketamine, are we there yet?

F Dorandeu, F Dhote, L Barbier… - CNS neuroscience & …, 2013 - Wiley Online Library
Status epilepticus (SE), a neurological emergency both in adults and in children, could lead
to brain damage and even death if untreated. Generalized convulsive SE (GCSE) is the most …

Etiology, clinical course and response to the treatment of status epilepticus in children: a 16-year single-center experience based on 602 episodes of status epilepticus

R Kravljanac, M Djuric, B Jankovic… - european journal of …, 2015 - Elsevier
Objective evaluation of etiology, clinical course and response to the treatment of status
epilepticus (SE) in children, with particular investigation of superrefractory SE. Materials and …