The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of
E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. In …

Simple Summary The TP53 tumor suppressor gene, the guardian of the genome, is mutated
or has an inactive pathway in most chemo-resistant tumors. Most studies focus on the role of …

The p53 family member p63 exists as two major protein variants (TAp63 and ΔNp63) with
distinct expression patterns and functional properties. Whilst downstream target genes of …

The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is
known to play a dual role as both tumor suppressor and oncogene, and to function at the …

Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the
population and, as all malignant tumors, often develops resistance to chemotherapies with …

Simple Summary The tripartite motif (TRIM) gene family is a large group of E3 ubiquitin
ligase proteins that can also have proteasome-independent functions. This review …

Background Ovarian cancer is a common gynecological tumor with high malignant potential
and poor prognosis. TRIM8, is involved in the development of various tumors, but its precise …

Background Cervical cancer, as a common gynecological disease, endangers female
health. Give the lack of effective biomarkers for the diagnosis and treatment of cervical …

Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most
lethal central nervous system tumors in adults. Despite significant breakthroughs in standard …

The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of
E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly increased in recent years. In …