Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …

Immune thrombocytopenia (ITP) is a common hematological manifestation of systemic lupus
erythematosus (SLE). The heterogeneity of its clinical characteristics and therapeutic …

Haematological complications are frequently seen in SLE. Anaemia, leucopenias and
thrombocytopenia may result from bone marrow failure or excessive peripheral cell …

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease
affecting multiple organ systems that runs an unpredictable course and may present with a …

Evidence from many human and rodent studies has established that T lymphocytes enhance
inflammation in atherosclerotic plaques and contribute to lesion progression and …

The role of CD40/CD40 ligand (CD40L) interactions in atherothrombosis, in the response of
the immune system to pathogens and in thrombosis is now widely accepted. A role for CD40 …

Various hematological pathologies have been described in association with
antiphospholipid syndrome (APS). Thrombocytopenia is frequently found in APS patients, its …

The association between antiphospholipid antibodies (aPL) and clinical problems goes
beyond what is stated in the antiphospholipid syndrome (APS) classification criteria, namely …

TNF-related ligands (with the exception of lymphotoxin-α) are synthesized as type II
transmembrane proteins, though many of them also have soluble forms. An increasing …