Highlights•Data independent MS/MS acquisition methods improve metabolite
identification.•A step-by-step workflow is needed to assess the accuracy of metabolite …

As researchers are increasingly able to collect data on a large scale from multiple clinical
and omics modalities, multi-omics integration is becoming a critical component of …

A key concept in drug discovery is the identification of candidate therapeutic targets such as
long noncoding RNAs (lncRNAs) because of their extensive involvement in neoplasms, and …

Introduction: Cigarette smoking has been associated with adverse health outcomes for
mothers and children and is a major contributor to heart disease. Although cigarette smoking …

Background The combination of sodium bisulfite treatment with highly-parallel sequencing is
a common method for quantifying DNA methylation across the genome. The power to detect …

The purpose of this review is to explore how metabolomics can help uncover new
biomarkers and mechanisms for cardiovascular ageing. Cardiovascular ageing refers to …

Triage and medical intervention strategies for unanticipated exposure during a radiation
incident benefit from the early, rapid and accurate assessment of dose level. Radiation …

Thioredoxin-interacting protein (TXNIP) plays a key role in diabetes development and
prognosis through its role in pancreatic β-cell dysfunction and death as well as in …

The pharmacoepigenetic apparatus is integrated by gene clusters of different categories,
including (i) pathogenic genes involved in disease pathogenesis,(ii) mechanistic genes …

Epigenome‐wide association studies (EWAS) identify genes that are dysregulated by the
studied clinical endpoints, thereby indicating potential new diagnostic biomarkers, drug …