Specific Extracellular Vesicles, Generated and Operating at Synapses, Contribute to Neuronal Effects and Signaling

J Meldolesi - International Journal of Molecular Sciences, 2024 - mdpi.com
In all cell types, small EVs, very abundant extracellular vesicles, are generated and
accumulated within MVB endocytic cisternae. Upon MVB fusion and exocytosis with the …

Phosphatidylinositol-3-phosphate mediates Arc capsid secretion through the multivesicular body pathway

K Mehta, H Yentsch, J Lee, Y Yook, KY Lee… - Proceedings of the …, 2024 - pnas.org
Activity-regulated cytoskeleton-associated protein (Arc/Arg3. 1) is an immediate early gene
that plays a vital role in learning and memory. Arc protein has structural and functional …

Arc mediates intercellular tau transmission via extracellular vesicles

M Tyagi, R Chadha, E de Hoog, KR Sullivan… - …, 2024 - pmc.ncbi.nlm.nih.gov
Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause
neurodegeneration in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Tau …