The dual role of the pancreas as both an endocrine and exocrine gland is vital for food
digestion and control of nutrient metabolism. The exocrine pancreas secretes enzymes into …

Abstract Calcium ion (Ca2+) is a multifaceted signaling molecule that acts as an important
second messenger. During the course of evolution, plants and animals have developed …

Objectives Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects
with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a …

The semi‐essential ubiquitous amino acid taurine has been shown to alleviate obesity and
hyperglycemia in humans; however, the pathways underlying the antidiabetic actions have …

The acute mouse pancreatic tissue slice is a unique in situ preparation with preserved
intercellular communication and tissue architecture that entails significantly fewer …

Although mice are a very instrumental model in islet beta cell research, possible phenotypic
differences between strains and substrains are largely neglected in the scientific community …

Aim Despite its abundance in pancreatic islets of Langerhans and proven antihyperglycemic
effects, the impact of the essential amino acid, taurine, on islet β‐cell biology has not yet …

Adrenaline inhibits insulin secretion from pancreatic beta cells to allow an organism to cover
immediate energy needs by unlocking internal nutrient reserves. The stimulation of α2 …

Aims Despite its high concentration in pancreatic islets of Langerhans and broad range of
antihyperglycemic effects, the route facilitating the import of dietary taurine into pancreatic β …

Reversible phosphorylation is an important regulatory mechanism. Regulation of protein
phosphorylation in β-cells has been extensively investigated, but less is known about …