Enterohepatic circulation serves to capture bile acids and other steroid metabolites
produced in the liver and secreted to the intestine, for reabsorption back into the circulation …

Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …

Abstract The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from
September 2016 through February 2017. This challenge was based on a dataset of …

The Farnesoid X Receptor (FXR) was recently validated in clinical studies using the bile acid
analogue Obeticholic Acid (OCA) as an attractive drug target for liver diseases such as …

The farnesoid X receptor (FXR) belonging to the metabolic subfamily of nuclear receptors is
a ligand-induced transcriptional activator. Its central function is the physiological …

The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as
cellular sensor for bile acids. In this role, FXR is a highly important liver protector and FXR …

The modulation of FXR receptor remains an attractive area in drug discovery to develop
novel therapeutic opportunities for liver and metabolic disorders. Despite the large variety of …

To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic
naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist …

Within our efforts in the discovery of novel potent and selective ligands for the FXR receptor,
23-N-(carbocinnamyloxy)-3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine was …

Molecular docking is a powerful tool in the field of computer-aided molecular design. In
particular, it is the technique of choice for the prediction of a ligand pose within its target …