The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Abstract The Cancer Programme of the 100,000 Genomes Project was an initiative to
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …

Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all,
human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms …

Only a subset of patients treated with immune checkpoint inhibitors (CPIs) respond to the
treatment, and distinguishing responders from non-responders is a major challenge. Many …

To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer
progression, we detected and classified focal amplifications in 8,060 newly diagnosed …

Studies have characterized the immune escape landscape across primary tumors. However,
whether late-stage metastatic tumors present differences in genetic immune escape (GIE) …

Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …