Mechanisms, evaluation, and management of chronic constipation

AE Bharucha, BE Lacy - Gastroenterology, 2020 - Elsevier
With a worldwide prevalence of 15%, chronic constipation is one of the most frequent
gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source …

Faecal incontinence in adults

AE Bharucha, CH Knowles, I Mack, A Malcolm… - Nature Reviews …, 2022 - nature.com
Faecal incontinence, which is defined by the unintentional loss of solid or liquid stool, has a
worldwide prevalence of≤ 7% in community-dwelling adults and can markedly impair …

Understanding the physiology of human defaecation and disorders of continence and evacuation

PT Heitmann, PF Vollebregt, CH Knowles… - Nature reviews …, 2021 - nature.com
The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

American Gastroenterological Association technical review on constipation

AE Bharucha, JH Pemberton, GR Locke - Gastroenterology, 2013 - gastrojournal.org
This article has an accompanying continuing medical education activity on page e19.
Learning Objective: Upon completion of this exam, successful learners will recognize the …

Chronic constipation

AE Bharucha, A Wald - Mayo Clinic Proceedings, 2019 - Elsevier
Constipation is a common symptom that may be primary (idiopathic or functional) or
associated with a number of disorders or medications. Although most constipation is self …

Advances in the evaluation of anorectal function

EV Carrington, SM Scott, A Bharucha, F Mion… - Nature reviews …, 2018 - nature.com
Faecal incontinence and evacuation disorders are common, impair quality of life and incur
substantial economic costs worldwide. As symptoms alone are poor predictors of underlying …

[HTML][HTML] Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment)

A Bove, M Bellini, E Battaglia, R Bocchini… - World journal of …, 2012 - ncbi.nlm.nih.gov
The second part of the Consensus Statement of the Italian Association of Hospital
Gastroenterologists and Italian Society of Colo-Rectal Surgery reports on the treatment of …

Opioid-induced bowel dysfunction: pathophysiology and management

C Brock, SS Olesen, AE Olesen, JB Frøkjaer… - Drugs, 2012 - Springer
Opioids are the most commonly prescribed medications to treat severe pain in the Western
world. It has been estimated that up to 90% of American patients presenting to specialized …

[HTML][HTML] How to perform and interpret a high-resolution anorectal manometry test

TH Lee, AE Bharucha - Journal of neurogastroenterology and …, 2016 - ncbi.nlm.nih.gov
High-resolution anorectal manometry (HR-ARM) and high-definition anorectal manometry
(HD-ARM) catheters have closely spaced water-perfused or solid state circumferentially …

A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation

EV Carrington, J Evers, U Grossi… - …, 2014 - Wiley Online Library
Background Sacral nerve stimulation (SNS) is now well established as a treatment for fecal
incontinence (FI) resistant to conservative measures and may also have utility in the …