Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around
the world. With increasing rates of incidence and prevalence worldwide, OA has become an …

Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect
muscle, bone, cartilage, joint and connective tissue, leading to physical and functional …

Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked
intensive interest. Initially considered as the transcriptional noises, further studies have …

Aims Osteoarthritis (OA) is a common degenerative disease that is pathologically
characterized by destruction of the joint matrix and reduction of articular chondrocytes …

Background Long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR)
contributes to cartilage damages including osteoarthritis (OA). While, its role and mechanism …

Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular
cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The …

OBJECTIVE: Long non-coding RNA (lncRNA) participates in the pathogenesis of human
knee osteoarthritis (KOA). Growth arrest specificity 5 (GAS5) is a member lncRNA, but its …

X-box binding protein 1 (XBP1) is a critical component for unfolded protein response (UPR)
in ER stress. According to previous studies performed with different XBP1-deficient mice, the …

Osteoarthritis impairs the functions of various joints, such as knees, hips, hands and spine,
which causes pain, swelling, stiffness and reduced mobility in joints. Multiple factors …

Background: To study the effect of long non-coding RNA H19/microRNA (miR)-140-5p
regulatory axis on the degradation and calcification of osteoarthritis (OA) cartilage matrix …