[HTML][HTML] Bioelectric signaling in regeneration: mechanisms of ionic controls of growth and form

KA McLaughlin, M Levin - Developmental biology, 2018 - Elsevier
The ability to control pattern formation is critical for the both the embryonic development of
complex structures as well as for the regeneration/repair of damaged or missing tissues and …

Aging and longevity in the simplest animals and the quest for immortality

RS Petralia, MP Mattson, PJ Yao - Ageing research reviews, 2014 - Elsevier
Here we review the examples of great longevity and potential immortality in the earliest
animal types and contrast and compare these to humans and other higher animals. We start …

Planarian regeneration as a model of anatomical homeostasis: recent progress in biophysical and computational approaches

M Levin, AM Pietak, J Bischof - Seminars in cell & developmental biology, 2019 - Elsevier
Planarian behavior, physiology, and pattern control offer profound lessons for regenerative
medicine, evolutionary biology, morphogenetic engineering, robotics, and unconventional …

Physiological controls of large‐scale patterning in planarian regeneration: a molecular and computational perspective on growth and form

F Durant, D Lobo, J Hammelman, M Levin - Regeneration, 2016 - Wiley Online Library
Planaria are complex metazoans that repair damage to their bodies and cease remodeling
when a correct anatomy has been achieved. This model system offers a unique opportunity …

The expanding epigenetic landscape of non-model organisms

R Bonasio - Journal of Experimental Biology, 2015 - journals.biologists.com
Epigenetics studies the emergence of different phenotypes from a single genotype. Although
these processes are essential to cellular differentiation and transcriptional memory, they are …

[HTML][HTML] CBP/p300 homologs CBP2 and CBP3 play distinct roles in planarian stem cell function

CR Stelman, BM Smith, B Chandra… - Developmental …, 2021 - Elsevier
Chromatin modifications function as critical regulators of gene expression and cellular
identity, especially in the regulation and maintenance of the pluripotent state. However …

[HTML][HTML] CREB-binding protein (CBP) gene family regulates planarian survival and stem cell differentiation

S Fraguas, S Cárcel, C Vivancos, MD Molina… - Developmental …, 2021 - Elsevier
In developmental biology, the regulation of stem cell plasticity and differentiation remains an
open question. CBP (CREB-binding protein)/p300 is a conserved gene family that functions …

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs

HR Vaca, AM Celentano, MA Toscanini… - PLoS Neglected …, 2021 - journals.plos.org
Background Echinococcosis and cysticercosis are neglected tropical diseases caused by
cestode parasites (family Taeniidae). Not only there is a small number of approved …

Planarian flatworms as a new model system for understanding the epigenetic regulation of stem cell pluripotency and differentiation

A Dattani, D Sridhar, AA Aboobaker - Seminars in cell & developmental …, 2019 - Elsevier
Planarian flatworms possess pluripotent stem cells (neoblasts) that are able to differentiate
into all cell types that constitute the adult body plan. Consequently, planarians possess …

Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians

LL Wong, CG Bruxvoort, NI Cejda, MR Delaney… - Nature …, 2022 - nature.com
Lipid metabolism plays an instructive role in regulating stem cell state and differentiation.
However, the roles of lipid mobilization and utilization in stem cell-driven regeneration are …