The intracellular domain (ICD) of Cys-loop receptors mediates diverse functions. To date, no
structure of a full-length ICD is available due to challenges stemming from its dynamic …

The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous
system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric …

PDZ domains are modular domains that conventionally bind to C terminal or internal motifs
of target proteins to control cellular functions through the regulation of protein complex …

Co-use of xylazine with opioids is a major health threat in the United States. However, a
critical knowledge gap exists in the understanding of xylazine-induced pharmacological and …

Quaternary distance restraints are essential to define the three-dimensional structures of
protein assemblies. These distances often fall within a range of 10–18 Å, which challenges …

Although the functional properties of ion channels are most accurately assessed using
electrophysiological approaches, a number of experimental situations call for alternative …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fast
cholinergic synaptic transmission in nervous system. In insects, nAChRs are the target sites …

The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in various intracellular
signaling pathways that mediate addiction, chronic pain, and other diseases, but its …

The study of the conformational changes occurring in a protein structure is essential to
understand its function and how a protein can be modulated. This research project was …

Silent agonists are α7 nicotinic acetylcholine receptor ligands that do not evoke a response
larger than 10% of the acetylcholine control but put the receptor into a desensitized state (D …