Multifunctional ECM proteins in bone and teeth

S Ravindran, A George - Experimental cell research, 2014 - Elsevier
The extracellular matrix (ECM) of all tissues and organs is a highly organized and complex
structure unique to the specific organ type. The ECM contains structural and functional …

[HTML][HTML] The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein

H Ritchie - International Journal of Oral Science, 2018 - nature.com
Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous
proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator …

[HTML][HTML] DSPP dosage affects tooth development and dentin mineralization

D Lim, KC Wu, A Lee, TL Saunders, HH Ritchie - PLoS One, 2021 - journals.plos.org
Dentin Sialoprotein (DSP) and phosphophoryn (PP) are two most dominant non-
collagenous proteins in dentin, which are the cleavage products of the DSPP (dentin …

Promotion of dental pulp cell migration and pulp repair by a bioceramic putty involving FGFR-mediated signaling pathways

J Zhang, LX Zhu, X Cheng, Y Lin… - Journal of dental …, 2015 - journals.sagepub.com
Mineral trioxide aggregate is the currently recommended material of choice for clinical pulp
repair despite several disadvantages, including handling inconvenience. Little is known …

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

L Zhu, J Yang, J Zhang, D Lei, L Xiao, X Cheng, Y Lin… - Acta biomaterialia, 2014 - Elsevier
Bioactive materials play an important role in facilitating dental pulp repair when living dental
pulp is exposed after injuries. Mineral trioxide aggregate is the currently recommended …

Dentin sialophosphoprotein: a regulatory protein for dental pulp stem cell identity and fate

S Guo, D Lim, Z Dong, TL Saunders, PX Ma… - Stem cells and …, 2014 - liebertpub.com
The dentin sialophosphoprotein (dspp) transcript is expressed during tooth development as
a DSPP precursor protein, which then undergoes cleavage to form mature dentin …

DSPP contains an IRES element responsible for the translation of dentin phosphophoryn

Y Zhang, Y Song, S Ravindran, Q Gao… - Journal of dental …, 2014 - journals.sagepub.com
The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin
phosphophoryn (DPP). DPP appears to be synthesized as a part of a larger compound …

[HTML][HTML] Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif

S Suzuki, S Kobuke, N Haruyama, H Hoshino… - PloS one, 2014 - journals.plos.org
Phosphophoryn (PP) is generated from the proteolytic cleavage of dentin
sialophosphoprotein (DSPP). Gene duplications in the ancestor dentin matrix protein-1 …

Site specificity of DSP-PP cleavage by BMP1

RT Yang, GL Lim, CT Yee, RS Fuller… - Connective Tissue …, 2014 - Taylor & Francis
Abstract Bone morphogenic protein 1 (BMP1), a metalloproteinase, is known to cleave a
wide variety of extracellular matrix proteins, suggesting that a consensus substrate cleavage …

[HTML][HTML] DSP-PP C-Terminal Conservation Is Crucial for Accurate DSP-PP Precursor Cleavage

KC Wu, HH Ritchie - Dentistry (Lisle, Ill.), 2017 - ncbi.nlm.nih.gov
Abstract Dentin Sialoprotein (DSP) and Phosphophoryn (PP), acidic proteins critical to
dentin mineralization, are translated from a single transcript as a DSP-PP precursor that …