Autoantibodies against autologus tumor‐associated antigens have been detected in the
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …

Cancer remains a leading cause of death worldwide due to the lack of safer and more
effective therapies. Cancer vaccines developed from neoantigens are an emerging strategy …

Despite the paradigm that carbohydrates are T cell–independent antigens, isotype-switched
glycan-specific immunoglobulin G (IgG) antibodies and polysaccharide-specific T cells are …

For early detection of cancer, education and screening are important, but the most critical
factor is the development of early diagnostic tools. Methods that recognize the warning signs …

Glycans are part of the essential components of a cell. These compounds play a
fundamental role in several physiopathological processes, including cell differentiation …

Tumor-associated carbohydrate antigens (TACAs) support cell survival that could be
interrupted by anti-TACA antibodies. Among TACAs that mediate cell survival signals are the …

Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled
plasma from thousands of healthy donors and are being tested in preclinical mouse models …

Cancer constitutes the second leading cause of death globally and is considered to have
been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against …

Aberrant N-linked glycosylation is a prominent feature of cancers. Perturbance of
oligosaccharide structure on cell surfaces directly affects key processes in tumor …

Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent
infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to …