The paradox of aerobic life, or the'Oxygen Paradox', is that higher eukaryotic aerobic
organisms cannot exist without oxygen, yet oxygen is inherently dangerous to their …

Oxidative stress, through the production of reactive oxygen species, is a natural
consequence of aerobic metabolism. Escherichia coli has several major regulators activated …

DNA amplification is essential to most nucleic acid testing strategies, but established
techniques require sophisticated equipment or complex experimental procedures, and their …

Natural-product-derived cytotoxics remain a mainstay in current chemotherapy. 1 This
review focuses on the current level of understanding and emerging trends relevant to the …

Abasic (AP) sites are common, potentially mutagenic DNA damages that are attacked by AP
endonucleases. The biological roles of these enzymes in metazoans have not been tested …

Escherichia coli responds to superoxide-generating agents by inducing approximately 40
proteins. We have identified a genetic locus, soxR (superoxide response), that positively …

Studies on the enzymology of apurinic/apyrimidinic (AP) endonucleases from procaryotic
and eucaryotic organisms are reviewed. Emphasis will be placed on the enzymes from …

A significant fraction of DNA damage produced by ionizing radiation comes from free
radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl …

A list of currently identified gene products of Escherichia coli is given, together with a
bibliography that provides pointers to the literature on each gene product. A scheme to …

The soxR locus of Escherichia coli K12 mediates transcriptional activation of a complex
oxidative stress regulon in response to superoxide-generating (redox cycling) agents. We …