Genome-wide genealogies compactly represent the evolutionary history of a set of genomes
and inferring them from genetic data has the potential to facilitate a wide range of analyses …

The observation of genetic correlations between disparate human traits has been
interpreted as evidence of widespread pleiotropy. Here, we introduce cross-trait assortative …

Over the past decade, statistical methods have been developed to estimate single
nucleotide polymorphism (SNP) heritability, which measures the proportion of phenotypic …

Single nucleotide polymorphisms (SNPs) are the most abundant type of genomic variation
and the most accessible to genotype in large cohorts. However, they individually explain a …

African populations are vastly underrepresented in genetic studies but have the most
genetic variation and face wide-ranging environmental exposures globally. Because …

Genetic effects on gene expression and splicing can be modulated by cellular and
environmental factors; yet interactions between genotypes, cell type, and treatment have not …

The genetic variants introduced into the ancestors of modern humans from interbreeding
with Neanderthals have been suggested to contribute an unexpected extent to complex …

The contribution of gene-by-environment (GxE) interactions for many human traits and
diseases is poorly characterized. We propose a Bayesian whole-genome regression model …

Gene-environment interactions (GxE) can be fundamental in applications ranging from
functional genomics to precision medicine and is a conjectured source of substantial …

The proportion of variation in complex traits that can be attributed to non-additive genetic
effects has been a topic of intense debate. The availability of biobank-scale datasets of …