Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Functional interaction between neurons and glia is an exciting field that has expanded
tremendously during the past decade. Such partnership has multiple impacts on neuronal …

Abstract Connexin-43 (Cx43), a predominant cardiac connexin, forms gap junctions (GJs)
that facilitate electrical cell–cell coupling and unapposed/nonjunctional hemichannels that …

Adenosine triphosphate (ATP) plays a fundamental role in cellular communication, with its
extracellular accumulation triggering purinergic signaling cascades in a diversity of cell …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

Plasma membrane hemichannels composed of connexin (Cx) proteins are essential
components of gap junction channels but accumulating evidence suggests functions of …